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Under REMS, abortion pills can only be distributed by qualified clinicians at approved hospitals and clinics. If the restrictions were lifted, non-doctors would be able to sell abortion pills online directly to consumers or ship them to pharmacies.
Self-managed abortions using the abortion pill regimen can be risky since no medical professional is present to intervene if complications arise, which isn't uncommon. In 8% of self-managed abortion cases documented by a TelAbortion study, women sought follow-up care at a medical facility. That number is probably smaller than what would occur in an uncontrolled environment as well since not all women would have the advice of a trained study clinician vetted by an organization trying to prove that telemedical abortion is safe.